Urolithin A Choline Salt

Urolithin A Choline Salt offers a salt-form option for brands exploring healthy-aging and muscle-health formulations. Its scientific story begins with urolithin A, a compound studied for mitochondrial quality control and selected measures of muscle function.

Youyou Biotechnology supplies Urolithin A Choline Salt as a yellow powder with ≥99.0% HPLC purity and ≥95.0% NMR assay for ingredient evaluation and formulation development.

Urolithin A Choline Salt is a salt form of urolithin A that uses choline as the counterion. It provides a distinct material option for formulators evaluating urolithin A ingredients.

Urolithin A can be produced when certain gut microorganisms metabolize dietary compounds found in foods such as pomegranates and walnuts. This conversion varies between individuals. Urolithin A ingredients provide the compound without relying on that dietary conversion step; absorption still depends on the preparation and the individual.

About the evidence: The published studies summarized below investigated specific urolithin A preparations, not this Urolithin A Choline Salt product. They provide scientific context and do not establish equivalent efficacy, safety, dosage, or bioavailability for this salt form.

Mitochondria help cells produce usable energy. Their function depends partly on quality-control processes that remove damaged components. One of these processes is mitophagy: the selective recycling of damaged or dysfunctional mitochondria.

Urolithin A has been investigated for its role in this process, linking cellular research with human studies of muscle function. This research provides a rationale for exploring urolithin A in healthy-aging nutrition.

1.Mitochondrial Quality Control —— Development focus: mitochondrial-health and cellular-wellness concepts. Biomarker findings do not establish an increase in everyday energy levels.

2.Muscle Endurance —— Development focus: muscle-health and active-aging concepts.

3.Muscle Strength —— Development focus: nutrition concepts centered on maintaining muscle function through midlife.

4.Healthy Aging —— Development focus: daily nutrition concepts for adults interested in maintaining physical function as they age. Current evidence does not establish human lifespan extension or reversal of aging.

Uses a salt formation and crystal engineering strategy with choline as a counterion to disrupt the strong intermolecular hydrogen bond network of Urolithin A's phenolic hydroxyl groups, lowering lattice energy.

High-throughput crystallization screening identified "Type A" as the thermodynamically stable crystal form with optimal solubility and physicochemical stability.

In simulated intestinal fluid (FaSSIF, pH 6.5), the choline salt Type A reached a solubility of 3.6 µg/mL at 1 hour (about 13 times higher than the free state).

In pure water, it achieved an exponential leap to 1,542.3 µg/mL at 0.5 hours, whereas the free state remained below the detection limit.

• Rat pharmacokinetic studies confirmed a relative bioavailability of 216% (AUC increased from 18,626 to 40,219 ng h/mL).

• Peak concentration (Cmax) increased approximately 5-fold from 1,632 to 8,085 ng/mL.

• Time to peak (Tmax) was shortened from 4 hours to 1 hour, facilitating rapid onset.

Through the dual strategy of salt formation and crystal engineering, the Urolithin A choline salt Type A has restructured the drug's dissolution and absorption behavior at the molecular level. in vitro solubility improved by up to thousands of times in aqueous media and approximately 13-fold in simulated intestinal fluid, in vivo bioavailability increased by 216%, and Cmax increased approximately 5-fold. The complete evidence chain proves that this salt form is a novel solid form with high stability, high solubility, and high bioavailability, establishing a new benchmark for the efficient oral delivery of Urolithin A.